Artificial Lipid Bilayers in a Microfabricated System
نویسندگان
چکیده
A microfabricated silicon device for studying artificial lipid bilayer systems is described. The experimental apparatus employed enabled the simultaneous acquisition of electrical and optical data. Reconstitution of channel-forming proteins into a artificial lipid bilayer formed across an aperture in the silicon device is demonstrated.
منابع مشابه
Controlled delivery of membrane proteins to artificial lipid bilayers by nystatin-ergosterol modulated vesicle fusion.
The study of ion channels and other membrane proteins and their potential use as biosensors and drug screening targets require their reconstitution in an artificial membrane. These applications would greatly benefit from microfabricated devices in which stable artificial lipid bilayers can be rapidly and reliably formed. However, the amount of protein delivered to the bilayer must be carefully ...
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